Insulin-like Growth Factor-1 (IGF-1) 1 mg × 10 vials — Research-Grade Recombinant Insulin-like Growth Factor-1

Document ID: HKPW-igf-1-1-mg-research-peptide-usa-v1.0 | Reviewed by: HKPEPTIDE WORLDWIDE Research Team | Last Updated: 2026-08-08

Product Identity & Specifications

Parameter	Specification
Product Name	Insulin-like Growth Factor-1 (IGF-1)
Dosage	1 mg × 10 vials
CAS Number	67763-96-6
Molecular Formula	C₃₃₁H₅₁₂N₉₄O₁₀₁S₇
Molecular Weight	~7,649 Da
Sequence	70-amino acid polypeptide with 3 disulfide bonds
Purity	≥99% HPLC
Appearance	White to off-white lyophilized powder
Solubility	Soluble in sterile water or bacteriostatic water
Storage	2–8°C, desiccated, protected from light
Classification	Recombinant Insulin-like Growth Factor-1

Research Background

Insulin-like Growth Factor-1 (IGF-1) is a 70-amino acid polypeptide that serves as the primary mediator of Growth Hormone’s anabolic effects. Produced primarily in the liver in response to GH-induced GHR-JAK2-STAT5 signaling, IGF-1 circulates in a ternary complex with IGFBP-3 and ALS (acid-labile subunit). In research applications, recombinant IGF-1 enables direct study of IGF-1R signaling independent of GH receptor activation — allowing researchers to dissect GH’s IGF-1-dependent effects from its direct GHR-mediated actions. IGF-1 research spans skeletal muscle hypertrophy, bone growth, neuroprotection, and cellular senescence pathways.

The 1 mg × 10 vials configuration is manufactured under strict quality control protocols. Each batch undergoes HPLC purity verification, ESI-MS identity confirmation, and amino acid analysis. A batch-specific Certificate of Analysis (COA) is included with every order. Bulk and OEM configurations available for qualifying wholesale accounts.

Molecular Mechanisms

IGF-1R Activation

Binding to IGF-1 receptor (tyrosine kinase) → receptor autophosphorylation → IRS-1/PI3K/Akt and Shc/Ras/MAPK signaling cascades → protein synthesis, cell survival, and proliferation. IGF-1R shares structural homology with insulin receptor but has distinct ligand affinity and tissue distribution.

PI3K/Akt/mTOR Pathway

IGF-1R → IRS-1 → PI3K → PIP₃ → Akt → mTORC1 activation → protein translation initiation (via 4E-BP1 and S6K1). This is the primary anabolic signaling cascade mediating IGF-1’s effects on skeletal muscle protein synthesis and hypertrophy.

Cell Survival (Anti-Apoptotic)

Akt-mediated phosphorylation and inactivation of Bad, caspase-9, and FOXO transcription factors → mitochondrial stabilization and reduced apoptosis. Important in neuroprotection and cardioprotection research.

IGFBP Regulation

IGF-1 bioavailability is tightly regulated by six IGF-binding proteins (IGFBP-1 through -6). IGFBP-3 is the major circulating carrier, forming a ternary complex with ALS that extends IGF-1 half-life from minutes to ~15 hours.

Research Applications

Skeletal Muscle Protein Synthesis
IGF-1R Signaling Pathway Research
Bone Growth & Development
Neuroprotection & Neuronal Survival
Cellular Senescence & Aging

Comparative Analysis

Compared to HGH: IGF-1 bypasses the GH receptor and directly activates IGF-1R. HGH activates the full GHR cascade including both IGF-1-dependent and direct GH effects. IGF-1 is preferred when studying isolated IGF-1R signaling; HGH is preferred when studying the complete GH response. Compared to PEG-MGF: PEG-MGF is the IGF-1Ec splice variant that specifically targets muscle satellite cells. Standard IGF-1 has broader tissue distribution and receptor activation profile.

Quality Control & Analytical Specifications

Parameter	Method	Specification
Purity	HPLC at 214 nm, C18 column	≥99.0% peak area
Identity (MW)	ESI-MS	~7,649 Da
Appearance	Visual inspection	White to off-white powder
Peptide Content	Amino acid analysis	≥80% net peptide
Residual Moisture	Karl Fischer titration	≤3%
Endotoxin	LAL assay	≤0.5 EU/mg

Available Configurations

Configuration	Content	Best For
Standard Kit	1 mg × 10 vials × 10 vials	Evaluation; protocol validation
Bulk Kit	Custom × 10 vials	Chronic studies; repeat orders
OEM/Private Label	Custom	Branded product development

Frequently Asked Questions

Q: How does IGF-1 differ from HGH?

HGH activates the GH receptor → multiple downstream effects including IGF-1 production. IGF-1 directly activates the IGF-1 receptor → downstream anabolic signaling. HGH = indirect (via IGF-1); IGF-1 = direct receptor activation. Research choice depends on whether studying the complete GH axis (HGH) or isolated IGF-1R signaling (IGF-1).

Q: What is the IGF-1/IGFBP-3/ALS ternary complex?

In circulation, >99% of IGF-1 is bound to IGFBP-3 and ALS in a 150 kDa ternary complex. This extends IGF-1 half-life from minutes (free) to ~15 hours (bound) and prevents hypoglycemia from insulin receptor cross-activation. Research-grade IGF-1 is supplied as free peptide for controlled reconstitution.

Q: What distinguishes IGF-1 from PEG-MGF?

PEG-MGF is the IGF-1Ec splice variant with a 24-aa E-domain that specifically targets muscle satellite (stem) cells. Standard IGF-1 (systemic/liver-derived) has broader tissue activity. PEG-MGF = satellite cell-specific; IGF-1 = systemic anabolic signaling.

Tiered Wholesale Pricing

Volume	Discount	For
1 kit	List price	Evaluation; competitive analysis
5+ kits	10% off	Initial portfolio expansion
20+ kits	20% off	Mid-size distributors
50+ kits	30% off	Regional distributors

Contact our team for 100+ kit custom pricing. Mixed-molecule orders qualify for combined volume tiers.

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Compliance Statement

FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary diagnostic, therapeutic, or prophylactic use. Not a dietary supplement, pharmaceutical ingredient, or approved drug. Researchers must comply with all applicable institutional, local, and national regulations.

IGF-1 1 mg