Human Growth Hormone (Somatropin) 40 mg × 10 vials — Research-Grade Recombinant Human Growth Hormone

Document ID: HKPW-hgh-40-mg-recombinant-growth-hormone-res-v1.0 | Reviewed by: HKPEPTIDE WORLDWIDE Research Team | Last Updated: 2026-08-08

Product Identity & Specifications

Parameter	Specification
Product Name	Human Growth Hormone (Somatropin)
Dosage	40 mg × 10 vials
CAS Number	12629-01-5
Molecular Formula	C₉₉₀H₁₅₂₈N₂₆₂O₃₀₀S₇
Molecular Weight	~22,125 Da
Sequence	191-amino acid polypeptide; 2 disulfide bonds (Cys⁵³-Cys¹⁶⁵, Cys¹⁸²-Cys¹⁸⁹)
Purity	≥99% HPLC
Appearance	White to off-white lyophilized powder
Solubility	Soluble in sterile water or bacteriostatic water
Storage	2–8°C, desiccated, protected from light
Classification	Recombinant Human Growth Hormone

Research Background

Human Growth Hormone (Somatropin) is a 191-amino acid polypeptide produced by recombinant DNA technology. With a molecular weight of approximately 22,125 Da and two disulfide bonds (Cys⁵³-Cys¹⁶⁵, Cys¹⁸²-Cys¹⁸⁹), HGH is one of the most extensively characterized protein hormones in biomedical research. Its primary mechanism involves direct activation of the Growth Hormone Receptor (GHR), a member of the class I cytokine receptor superfamily, leading to JAK2-STAT5 signaling and subsequent IGF-1 production in the liver and peripheral tissues. HGH research spans body composition, muscle protein metabolism, bone density, lipid metabolism, and the GH/IGF-1 endocrine axis. Unlike GH secretagogue peptides (CJC-1295, GHRP-2, Ipamorelin) which stimulate endogenous GH release, HGH provides exogenous, precisely-dosed GH receptor activation — enabling studies that require defined, reproducible GH exposure independent of pituitary function.

The 40 mg × 10 vials configuration is manufactured under strict quality control protocols at our ISO-certified facility. Each batch undergoes comprehensive analytical verification including HPLC purity analysis, mass spectrometry identity confirmation, and amino acid analysis. A batch-specific Certificate of Analysis (COA) is included with every order, documenting all quality parameters.

For research institutions requiring bulk quantities, we offer tiered wholesale pricing with volume discounts up to 30% on orders of 50+ kits. Custom configurations — including alternative vial fill weights, custom labeling, and OEM/private-label packaging — are available for qualifying wholesale accounts.

Molecular Mechanisms

GHR-JAK2-STAT5 Signaling

Direct binding to pre-dimerized GHR → conformational change → JAK2 transphosphorylation → STAT5 recruitment and phosphorylation → nuclear translocation → IGF-1, ALS, and IGFBP-3 gene transcription. This canonical pathway mediates the majority of HGH’s anabolic and growth-promoting effects.

IGF-1 Endocrine Axis

HGH-stimulated hepatic IGF-1 production → systemic IGF-1 elevation → autocrine/paracrine growth signaling in target tissues. IGF-1 is the primary mediator of HGH’s effects on longitudinal bone growth and skeletal muscle protein synthesis.

Lipolysis & Substrate Mobilization

Direct GHR activation on adipocytes → hormone-sensitive lipase phosphorylation → triglyceride hydrolysis → free fatty acid release. This lipolytic effect is a direct GH action independent of IGF-1.

Insulin Counter-Regulation

GH antagonizes insulin signaling at the post-receptor level → reduced insulin-stimulated glucose uptake in skeletal muscle → physiologically relevant glucose-sparing effect during fasting states.

Research Applications

Body Composition & Metabolism Research
GH/IGF-1 Endocrine Axis Studies
Muscle Protein Metabolism
Bone Density & Longitudinal Growth Models
Lipolysis & Substrate Utilization

Comparative Analysis

Compared to GH Secretagogues (CJC-1295, Ipamorelin, GHRP-2): HGH provides direct, dose-controlled GH receptor activation — independent of pituitary GHRH/GHS-R signaling. Secretagogues stimulate endogenous GH release (variable, pulsatile); HGH delivers precise exogenous dosing. Compared to IGF-1: HGH activates both IGF-1-dependent and IGF-1-independent signaling pathways, providing broader biological context. HGH is preferred when studying the full GH response including direct GHR effects that are not replicated by IGF-1 alone.

Quality Control & Analytical Specifications

Parameter	Method	Specification
Purity	HPLC at 214 nm, C18 column	≥99% HPLC
Identity (MW)	ESI-MS	~22,125 Da
Appearance	Visual inspection	White to off-white powder
Peptide Content	Amino acid analysis	≥80% net peptide
Residual Moisture	Karl Fischer titration	≤3%
Endotoxin	LAL assay	≤0.5 EU/mg
Sterility	0.22 μm membrane filtration	Sterile-filtered

Available Configurations

Configuration	Content	Best For
Standard Kit	40 mg × 10 vials × 10 vials	Evaluation; protocol validation
Bulk Kit	Custom × 10 vials	Chronic studies; repeat orders
OEM/Private Label	Custom configurations	Branded product development

Frequently Asked Questions

Q: What distinguishes HGH from GH secretagogue peptides?

HGH is the full 191-aa protein that directly activates the GH receptor. CJC-1295, Ipamorelin, and GHRPs stimulate the pituitary to release endogenous GH — variable, pulsatile, and dependent on pituitary function. HGH provides precise, reproducible dosing independent of endogenous GH secretion. Choice depends on research objective: direct GH effects vs endogenous GH axis regulation.

Q: What analytical methods verify HGH quality?

HPLC purity (>99%), SDS-PAGE for molecular weight confirmation (~22,125 Da), ESI-MS for intact mass verification, and RP-HPLC for related proteins/aggregates. SDS-PAGE under reducing conditions confirms the 22 kDa monomer band. Endotoxin testing (LAL, ≤0.5 EU/mg) included in every COA.

Q: How does HGH storage differ from smaller peptides?

HGH is a full protein and is more sensitive to agitation and thermal stress than short peptides. Do NOT vortex — gently swirl to reconstitute. Use sterile bacteriostatic water or 0.9% saline. Lyophilized powder: 2-8°C, 24-month stability. HGH is also light-sensitive — store vials in original light-protective packaging.

Q: What are the key differences between HGH and IGF-1 for research?

HGH activates the full GHR signaling cascade including both IGF-1-dependent and direct GH effects (lipolysis, insulin counter-regulation). IGF-1 bypasses GHR and directly activates IGF-1R. Research choice depends on whether the objective is to study the complete GH response (use HGH) or isolate IGF-1-specific signaling (use IGF-1).

Tiered Wholesale Pricing

Volume	Discount	For
1 kit	List price	Evaluation; competitive analysis
5+ kits	10% off	Initial portfolio expansion
20+ kits	20% off	Mid-size distributors
50+ kits	30% off	Regional distributors

Contact our research team for custom pricing on 100+ kit wholesale orders. Mixed-molecule orders qualify for combined volume tiers.

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Compliance Statement

FOR LABORATORY RESEARCH USE ONLY. This product is intended exclusively for in vitro laboratory research and scientific investigation by qualified professionals. Not for human or veterinary diagnostic, therapeutic, prophylactic, or any in vivo human application. Not a dietary supplement, pharmaceutical ingredient, drug, or approved medical device. Researchers must comply with all applicable institutional, local, state, and national regulations governing the procurement, handling, storage, and use of research chemicals.

HGH 40 mg