GHRP-2 5 mg
Research PeptideGHRP-2 (Pralmorelin) 5 mg × 10 vials — Research-Grade Ghrelin Receptor (GHS-R1a) Agonist
Document ID: HKPW-ghrp-2-acetate-5-mg-research-peptide-usa-v1.0 | Reviewed by: HKPEPTIDE WORLDWIDE Research Team | Last Updated: 2026-08-08
Product Identity & Specifications
| Parameter | Specification |
|---|---|
| Product Name | GHRP-2 (Pralmorelin) |
| Dosage | 5 mg × 10 vials |
| CAS Number | 158861-67-7 |
| Molecular Formula | C₄₅H₅₅N₉O₆ |
| Molecular Weight | ~817.0 Da |
| Sequence | D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH₂ |
| Purity | ≥99% HPLC |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in sterile water or bacteriostatic water |
| Storage | 2–8°C, desiccated, protected from light |
| Classification | Ghrelin Receptor (GHS-R1a) Agonist |
Research Background
GHRP-2 (Pralmorelin) is a synthetic hexapeptide ghrelin receptor (GHS-R1a) agonist developed by Kaken Pharmaceutical. It is one of the most potent GH secretagogues in the GHRP family, producing rapid, robust GH pulses through GHS-R1a activation on pituitary somatotrophs. Strategic D-amino acid modifications (D-Ala¹, D-2-Nal², D-Phe⁵) confer both high receptor affinity and resistance to enzymatic degradation. Compared to Ipamorelin (cleaner, more selective) and GHRP-6 (stronger hunger signaling), GHRP-2 occupies the middle ground — potent GH release with moderate selectivity. The acetate salt form provides optimal solubility for laboratory reconstitution.
The 5 mg × 10 vials configuration is manufactured under strict quality control protocols. Each batch undergoes HPLC purity verification, ESI-MS identity confirmation, and amino acid analysis. A batch-specific Certificate of Analysis (COA) is included with every order. Bulk and OEM configurations available for qualifying wholesale accounts.
Molecular Mechanisms
GHS-R1a Receptor Agonism
High-affinity ghrelin receptor binding → Gαq/PLC/IP₃ signaling → intracellular Ca²⁺ mobilization → GH vesicle exocytosis from pituitary somatotrophs. GHRP-2 demonstrates sub-nanomolar GHS-R1a affinity in competitive binding assays.
GHRH Signal Potentiation
GHS-R1a and GHRH-R pathways converge on the somatotroph via distinct second messengers (PLC/Ca²⁺ vs cAMP/PKA). Simultaneous activation produces synergistic GH release exceeding additive effects — the basis for CJC-1295 + GHRP-2 combination protocols.
Somatostatin Suppression
GHS-R1a activation in hypothalamic arcuate nucleus → reduced somatostatin release → removal of tonic GH inhibition → permissive window for amplified GH secretion.
Research Applications
- GH Pulse Induction Research
- GHS-R1a Receptor Pharmacology
- Pulsatile GH Secretion Models
- GHRH/GHS Combination Protocols
Comparative Analysis
Compared to Ipamorelin: GHRP-2 — more potent GH, less selectivity. Ipamorelin — cleaner pulse, minimal off-target. Compared to GHRP-6: GHRP-2 — less hunger, more selectivity.
Quality Control & Analytical Specifications
| Parameter | Method | Specification |
|---|---|---|
| Purity | HPLC at 214 nm, C18 column | ≥99.0% peak area |
| Identity (MW) | ESI-MS | ~817.0 Da |
| Appearance | Visual inspection | White to off-white powder |
| Peptide Content | Amino acid analysis | ≥80% net peptide |
| Residual Moisture | Karl Fischer titration | ≤3% |
| Endotoxin | LAL assay | ≤0.5 EU/mg |
Available Configurations
| Configuration | Content | Best For |
|---|---|---|
| Standard Kit | 5 mg × 10 vials × 10 vials | Evaluation; protocol validation |
| Bulk Kit | Custom × 10 vials | Chronic studies; repeat orders |
| OEM/Private Label | Custom | Branded product development |
Frequently Asked Questions
Q: How does GHRP-2 differ from Ipamorelin and GHRP-6?
GHRP-2: potent GH, moderate hunger, some ACTH/cortisol. Ipamorelin: cleanest GH, minimal hunger, highest selectivity. GHRP-6: strongest GH + hunger, closest ghrelin mimic. GHRP-2 is preferred when maximum GH amplitude is the priority.
Q: What is the optimal partner peptide?
CJC-1295 (no DAC) for pulsatile protocols: CJC provides GHRH signal, GHRP-2 suppresses somatostatin → synergistic GH pulse. The no-DAC variant (~30 min half-life) maintains the pulsatile pattern.
Q: What documentation is provided?
≥99% HPLC purity, ESI-MS identity (+/-1.0 Da), chiral HPLC for D-amino acid verification, amino acid analysis. Batch-specific COA with all test results.
Tiered Wholesale Pricing
| Volume | Discount | For |
|---|---|---|
| 1 kit | List price | Evaluation; competitive analysis |
| 5+ kits | 10% off | Initial portfolio expansion |
| 20+ kits | 20% off | Mid-size distributors |
| 50+ kits | 30% off | Regional distributors |
Contact our team for 100+ kit custom pricing. Mixed-molecule orders qualify for combined volume tiers.
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Compliance Statement
FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary diagnostic, therapeutic, or prophylactic use. Not a dietary supplement, pharmaceutical ingredient, or approved drug. Researchers must comply with all applicable institutional, local, and national regulations.
© 2026 HKPEPTIDE WORLDWIDE. All rights reserved. Document ID: HKPW-ghrp-2-acetate-5-mg-research-peptide-usa-v1.0