Delta Sleep-Inducing Peptide 5 mg × 10 vials — Research-Grade Delta Sleep-Inducing Nonapeptide

Document ID: HKPW-dsip-5-mg-research-peptide-usa-v1.0 | Reviewed by: HKPEPTIDE WORLDWIDE Research Team | Last Updated: 2026-08-08

Product Identity & Specifications

Parameter	Specification
Product Name	Delta Sleep-Inducing Peptide
Dosage	5 mg × 10 vials
CAS Number	62568-57-4
Molecular Formula	C₃₅H₄₈N₁₀O₁₅
Molecular Weight	~848.8 Da
Sequence	Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH
Purity	≥99% HPLC
Appearance	White to off-white lyophilized powder
Solubility	Soluble in sterile water or bacteriostatic water
Storage	2–8°C, desiccated, protected from light
Classification	Delta Sleep-Inducing Nonapeptide

Research Background

DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide first isolated from rabbit cerebral venous blood during electrically-induced slow-wave sleep by Monnier and Schoenenberger in the 1970s. The peptide’s sequence (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) was found to induce delta wave (0.5-4 Hz) EEG activity characteristic of deep, restorative sleep. Subsequent research expanded DSIP’s profile beyond sleep architecture: it modulates the HPA stress axis (reducing ACTH and corticosterone), produces opioid-independent analgesia, and influences circadian rhythm regulation. Its multifaceted profile — sleep modulation + stress reduction + non-opioid pain modulation — makes it a versatile research tool for studying the neuroendocrine integration of sleep, stress, and pain pathways.

The 5 mg × 10 vials configuration is manufactured under strict quality control protocols. Each batch undergoes HPLC purity verification, ESI-MS identity confirmation, and amino acid analysis. A batch-specific Certificate of Analysis (COA) is included with every order. Bulk and OEM configurations available for qualifying wholesale accounts.

Molecular Mechanisms

Delta Wave EEG Promotion

Slow-wave (0.5-4 Hz) EEG activity enhancement → increased deep sleep duration and sleep efficiency. The mechanism involves modulation of serotonergic and GABAergic tone in sleep-regulating brainstem and hypothalamic nuclei.

HPA Axis Modulation

Reduced ACTH release from anterior pituitary → lower circulating corticosterone → dampened stress axis activity. This effect is particularly relevant in stress-induced sleep disruption models.

Opioid-Independent Analgesia

Pain threshold elevation without μ, δ, or κ opioid receptor binding. The analgesic mechanism involves central serotonin and GABA pathways — a distinct non-opioid pain modulation system. This makes DSIP a valuable tool for studying non-opioid analgesic mechanisms.

Circadian Rhythm Regulation

Influence on suprachiasmatic nucleus (SCN) function and pineal melatonin synthesis → sleep-wake cycle modulation. DSIP’s effects on circadian timing are distinct from its direct sleep-promoting delta wave activity.

Research Applications

Sleep Architecture & Delta Wave Research
HPA Axis & Stress Response Studies
Non-Opioid Analgesia Mechanisms
Circadian Rhythm Regulation
Neuroendocrine Integration Research

Comparative Analysis

Compared to Melatonin: Melatonin primarily regulates sleep timing (circadian phase shifting via SCN). DSIP primarily affects sleep depth (delta wave promotion). They target different aspects of sleep physiology and can be studied in complementary protocols. DSIP’s additional stress-modulating and analgesic properties further differentiate its profile from melatonin and other sleep-regulating compounds.

Quality Control & Analytical Specifications

Parameter	Method	Specification
Purity	HPLC at 214 nm, C18 column	≥99.0% peak area
Identity (MW)	ESI-MS	~848.8 Da
Appearance	Visual inspection	White to off-white powder
Peptide Content	Amino acid analysis	≥80% net peptide
Residual Moisture	Karl Fischer titration	≤3%
Endotoxin	LAL assay	≤0.5 EU/mg

Available Configurations

Configuration	Content	Best For
Standard Kit	5 mg × 10 vials × 10 vials	Evaluation; protocol validation
Bulk Kit	Custom × 10 vials	Chronic studies; repeat orders
OEM/Private Label	Custom	Branded product development

Frequently Asked Questions

Q: How does DSIP differ from melatonin?

Melatonin: sleep timing (circadian phase). DSIP: sleep depth (delta waves). Melatonin works through MT1/MT2 receptors in the SCN. DSIP works through serotonergic/GABAergic modulation in sleep-regulating nuclei. Complementary — not redundant — research tools.

Q: Does DSIP work through opioid receptors?

No — a key research distinction. DSIP produces analgesia without binding μ, δ, or κ opioid receptors. Its analgesic mechanism involves central serotonin and GABA pathways. This makes DSIP a unique tool for studying non-opioid pain modulation.

Q: What is the origin of DSIP?

DSIP was discovered in the 1970s by Swiss researchers who electrically induced sleep in rabbits, collected cerebral venous blood, and isolated the factor that transferred sleep-inducing activity to recipient animals. The active nonapeptide was identified as Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu.

Tiered Wholesale Pricing

Volume	Discount	For
1 kit	List price	Evaluation; competitive analysis
5+ kits	10% off	Initial portfolio expansion
20+ kits	20% off	Mid-size distributors
50+ kits	30% off	Regional distributors

Contact our team for 100+ kit custom pricing. Mixed-molecule orders qualify for combined volume tiers.

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Compliance Statement

FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary diagnostic, therapeutic, or prophylactic use. Not a dietary supplement, pharmaceutical ingredient, or approved drug. Researchers must comply with all applicable institutional, local, and national regulations.

DSIP 5 mg