CJC-1295/Ipamorelin Blend 5 mg + 10 mg
Research PeptideCJC-1295 (no DAC) + Ipamorelin Combination CJC-1295 (no DAC) 5mg + Ipamorelin 10mg — Research-Grade GHRH/GHS-R Synergistic GH Secretagogue Blend
Document ID: HKPW-cjc-1295-without-dac-5-mg-ipa-10-mg-rese-v1.0 | Reviewed by: HKPEPTIDE WORLDWIDE Research Team | Last Updated: 2026-08-08
Product Identity & Specifications
| Parameter | Specification |
|---|---|
| Product Name | CJC-1295 (no DAC) + Ipamorelin Combination |
| Dosage | CJC-1295 (no DAC) 5mg + Ipamorelin 10mg |
| CAS Number | 863288-34-0 / 170851-70-4 |
| Molecular Formula | C₁₅₂H₂₅₂N₄₄O₄₂ / C₃₈H₄₉N₉O₅ |
| Molecular Weight | ~3,367.1 / ~711.9 Da |
| Sequence | CJC-1295: GHRH analogue |
| Purity | ≥99% HPLC |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in sterile water or bacteriostatic water |
| Storage | 2–8°C, desiccated, protected from light |
| Classification | GHRH/GHS-R Synergistic GH Secretagogue Blend |
Research Background
The CJC-1295 (no DAC) + Ipamorelin blend is the most studied GH secretagogue combination in preclinical research. CJC-1295 provides sustained GHRH receptor activation (the GH “on” switch), while Ipamorelin suppresses somatostatin tone through selective GHS-R1a agonism (removing the GH “off” switch). Together, they produce a synergistic GH pulse exceeding the additive effect of either peptide alone. The no-DAC CJC-1295 variant (~30 minute half-life) is specifically chosen for this blend to produce discrete, physiological GH pulses rather than sustained elevation. Each peptide is individually verified before combination, and the kit ships with unified COA documentation.
The CJC-1295 (no DAC) 5mg + Ipamorelin 10mg configuration is manufactured under strict quality control protocols. Each batch undergoes HPLC purity verification, ESI-MS identity confirmation, and amino acid analysis. A batch-specific Certificate of Analysis (COA) is included with every order. Bulk and OEM configurations available for qualifying wholesale accounts.
Molecular Mechanisms
GHRH Signal (CJC-1295)
GHRH-R activation on pituitary somatotrophs → cAMP/PKA → GH synthesis and vesicle mobilization. The no-DAC variant produces ~30 minute GHRH-R activation → discrete, physiological GH pulse.
Somatostatin Suppression (Ipamorelin)
Selective GHS-R1a activation → reduced hypothalamic somatostatin tone → removal of tonic GH inhibition. Ipamorelin’s selectivity minimizes ACTH/cortisol and hunger off-target effects.
Synergistic GH Pulse
GHRH signal + somatostatin suppression → amplified GH release. GHRH opens the gate; GHS-R removes the brake. The resulting GH pulse is larger than either peptide alone and closely mimics endogenous pulsatile secretion.
Research Applications
- Pulsatile GH Secretion Research
- GHRH/GHS-R Synergy Studies
- Body Composition Research
- Exercise-Induced GH Window Studies
Comparative Analysis
Compared to CJC-1295 (DAC) + Ipamorelin: The no-DAC blend produces discrete physiological GH pulses (~30 min). The DAC blend produces sustained GH elevation (~8 days). Choice depends on whether the research objective is pulsatile (no DAC) or sustained (DAC) GH signaling.
Quality Control & Analytical Specifications
| Parameter | Method | Specification |
|---|---|---|
| Purity | HPLC at 214 nm, C18 column | ≥99.0% peak area |
| Identity (MW) | ESI-MS | ~3,367.1 / ~711.9 Da |
| Appearance | Visual inspection | White to off-white powder |
| Peptide Content | Amino acid analysis | ≥80% net peptide |
| Residual Moisture | Karl Fischer titration | ≤3% |
| Endotoxin | LAL assay | ≤0.5 EU/mg |
Available Configurations
| Configuration | Content | Best For |
|---|---|---|
| Standard Kit | CJC-1295 (no DAC) 5mg + Ipamorelin 10mg × 10 vials | Evaluation; protocol validation |
| Bulk Kit | Custom × 10 vials | Chronic studies; repeat orders |
| OEM/Private Label | Custom | Branded product development |
Frequently Asked Questions
Q: Why pair CJC-1295 with Ipamorelin?
CJC-1295 provides the GHRH signal (GH ‘on’ switch). Ipamorelin suppresses somatostatin (removes GH ‘off’ switch). Together: synergistic GH pulse larger than either alone. Most studied GH secretagogue combination.
Q: Why no-DAC CJC-1295 for this blend?
No DAC = ~30 min half-life = discrete, physiological GH pulse. DAC variant = ~8 day half-life = sustained GH. Pulsatile protocols prefer no DAC; chronic elevation protocols prefer DAC.
Q: What documentation is provided?
Unified COA: individual HPLC purities, individual ESI-MS identities, combined kit batch number. Individual peptide COAs available on request.
Tiered Wholesale Pricing
| Volume | Discount | For |
|---|---|---|
| 1 kit | List price | Evaluation; competitive analysis |
| 5+ kits | 10% off | Initial portfolio expansion |
| 20+ kits | 20% off | Mid-size distributors |
| 50+ kits | 30% off | Regional distributors |
Contact our team for 100+ kit custom pricing. Mixed-molecule orders qualify for combined volume tiers.
Related Research & Resources
| Resource | Description |
|---|---|
| Healing Regenerative Peptides Hub | Complete research overview & methodology hub |
| Cjc 1295 With Dac 10 Mgin Vitro Research | Related research peptide product |
| Cjc 1295 With Dac 2 Mg Laboratory Resear | Related research peptide product |
| Why Muscle Growth Peptide Research Is Expanding | Latest research insights & methodology |
View Complete Research Guide »
Compliance Statement
FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary diagnostic, therapeutic, or prophylactic use. Not a dietary supplement, pharmaceutical ingredient, or approved drug. Researchers must comply with all applicable institutional, local, and national regulations.
© 2026 HKPEPTIDE WORLDWIDE. All rights reserved. Document ID: HKPW-cjc-1295-without-dac-5-mg-ipa-10-mg-rese-v1.0